Ceftiofur Hydrochloride (103980-44-5)
Bayanin Samfura
Ceftiofur maganin rigakafi ne na nau'in cephalosporin (ƙarni na uku), wanda aka ba da lasisi don amfani da shi a likitan dabbobi.An fara bayyana shi a cikin 1987.
Yana da juriya ga beta-lactamase na ƙwayoyin cuta na ƙwayoyin cuta, kuma yana da aiki a kan duka Gram-positive da Gram-negative bacteria.E. coli mai jure wa ceftiofur an ruwaito.
Ceftiofur Hydrochloride shine nau'in gishiri na hydrochloride na ceftiofur, semisynthetic, beta-lactamase-stable, m-bakan, cephalosporin ƙarni na uku tare da aikin ƙwayoyin cuta.Ceftiofur yana ɗaure kuma yana hana sunadaran da ke ɗaure penicillin (PBPs) waɗanda ke kan membrane na ciki na bangon ƙwayoyin cuta.PBPs sune enzymes da ke shiga cikin matakai na ƙarshe na haɗuwa da bangon kwayar cutar da kuma sake fasalin bangon tantanin halitta yayin girma da rarrabawa.Rashin kunnawa na PBPs yana tsoma baki tare da haɗin giciye na sarƙoƙi na peptidoglycan waɗanda suka wajaba don ƙarfin bangon ƙwayoyin ƙwayoyin cuta da rigidity.Wannan yana haifar da rauni na bangon kwayar cutar kwayan cuta kuma yana haifar da tantanin halitta.
| ABUBUWA | BAYANI | SAKAMAKO | |
| Bayyanar | Fari zuwa Kashe-fari Crystalline foda | Daidaita | |
| Ganewa | Lokacin riƙewa na babban kololuwa a cikin chromatogram da aka samu tare da maganin gwajin yayi daidai da na babban kololuwa a cikin chromatogram samu tare da bayani bayani. | Daidaita | |
| Maganin chloride | Daidaita | ||
| Bayyanar mafita | Tsaratarwa | Bai fi ƙarfin No.1 Turbidity Standard ba | <1 |
| Launi | Ba duhu fiye da daidaitaccen bayani Y9 ba | <8 | |
| Solubility | Mai narkewa a cikin N, N- Dimethylacetamide, dan kadan mai narkewa a cikin 5% na sodium bicarbonate da methanol. | Daidaita | |
| PH | 2.0 ~ 3.0 | 2.2 | |
| Abubuwan Ruwa | 1.5% ~ 4.0% | 1.6% | |
| Takamaiman Juyawar gani | -115°~-127° | -117° | |
| Karfe mai nauyi | NMT 0.0020% | Daidaita | |
| Ragowar ƙonewa | NMT 0.20% | 0.15% | |
| Abubuwan da ke da alaƙa | Mafi girman ƙazanta | NMT 0.20% | 0.09 |
| Jimlar ƙazanta | NMT 1.50% | 0.38 | |
| Ragowar kaushi | Ethyl acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0.006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0.0001 | |
| Assay | Ceftiofur Hydrochloride | NLT 98.0% | 100.4% |
| Chloride | 6.0% ~ 6.5% | 6.2% | |
| Bacterial Endotoxin | Kasa da 0.20EU/mg | Daidaita | |
| Haihuwa | Daidaita gwajin | Daidaita | |
| Girman barbashi | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| KAMMALAWA | SAKAMAKON JARRABAWA YANA DA KAMFANI | ||
