Glucose-6-phosphate dehydrogenase (G6PDH)

Glucose 6 phosphate dehydrogenase (G6PD) rashi yanayi ne na gado wanda jajayen ƙwayoyin jini ke rushewa (hemolysis) lokacin da jiki ya fallasa ga wasu abinci, magunguna, cututtuka ko damuwa.Yana faruwa lokacin da mutum ya ɓace ko yana da ƙananan matakan enzyme glucose-6-phosphate dehydrogenase.Wannan enzyme yana taimakawa ƙwayoyin jajayen jini suyi aiki yadda ya kamata.Alamomin da ke faruwa a lokacin aikin haemolytic na iya haɗawa da fitsari mai duhu, gajiya, kodadde, saurin bugun zuciya, ƙarancin numfashi, da launin rawaya na fata (jaundice).Ana gadon rashi G6PD ta hanyar koma bayan da aka danganta da X kuma alamun sun fi yawa a cikin maza (musamman Amurkawa Afirka da waɗanda suka fito daga wasu sassan Afirka, Asiya, da Bahar Rum).Ana haifar da shi ta hanyar canje-canjen kwayoyin halitta a cikin kwayar G6PD.

Glucose-6-Phophate Dehydrogenase (G-6-PDH) ya ƙunshi sassa biyu na daidaitattun nauyin kwayoyin halitta. An buga jerin amino acid na monomer.G-6-PDH an yi amfani da shi a cikin gwaje-gwaje don nicotinamide adenine dinucleotide da tissue pyridine. nucleotides.Ana iya sake kunna G-6-PDH daga hanyoyin da aka cire urea.

Glucose 6-phosphate dehydrogenase shine mabuɗin tsarin enzyme a matakin farko na hanyar pentose phosphate.G-6-P-DH oxidizes glucose-6-phosphate a gaban NADP⁺ don samar da 6-phosphogluconate.Polyacrylamide gel electrophoresis, lalata ayyuka, da anti-yisti G-6- PDH antibody immunoblotting binciken sun nuna cewa G-6-PDH glycoprotein ne.