Tranexamic acid (1197-18-8)
Bayanin Samfura
● Tranexamic Acid (1197-18-8)
● CAS No.:·1197-18-8
● EINECS Lamba: 356.2222
● MF: C8H15NO2
● Kunshin: 25Kg/Drum
● Tranexamic acid (TXA) magani ne da ake amfani da shi don magance ko hana zubar jini mai yawa daga manyan rauni, zubar jini bayan haihuwa, tiyata, cire hakori, zubar da jini, da yawan haila[2][3].Hakanan ana amfani dashi don angioedema na gado.[2][4]Ana shan shi ta baki ko kuma ta hanyar allura a cikin jijiya.
Hanyar aiki
Tranexamic acid analog ne na roba na amino acid lysine.Yana aiki azaman antifibrinolytic ta hanyar jujjuyawar ɗaure rukunin masu karɓar lysine huɗu zuwa biyar akan plasminogen.Wannan yana rage jujjuyawar plasminogen zuwa plasmin, yana hana lalata fibrin da kuma kiyaye tsarin tsarin matrix na fibrin. Tranexamic acid yana da kusan sau takwas aikin antifibrinolytic na tsohuwar analogue, ε-aminocaproic acid. Ayyukan plasmin tare da raunin rauni (IC50 = 87 mM), kuma yana iya toshe wurin aiki na urokinase plasminogen activator (uPA) tare da ƙayyadaddun ƙayyadaddun (Ki = 2 mM), ɗaya daga cikin mafi girma a cikin dukkanin ƙwayoyin serine.
Tranexamic acid ayyuka
Ana amfani da Tranexamic acid akai-akai bayan babban rauni.[13]Ana amfani da Tranexamic acid don hanawa da magance zubar jini a yanayi daban-daban, kamar hanyoyin haƙori, yawan zubar jinin al'ada, da tiyata tare da haɗarin zubar jini.
| Abubuwan Gwaji | Ma'auni na Pharmacopeial | Sakamakon Gwaji | |
| HALAYE | Bayyanar: Fari ko kusan fari, crystalline foda | Farar crystalline foda | |
| Solubility: Solubility da yardar kaina a cikin ruwa kuma a cikin glacial acetic acid, kusan ba zai iya narkewa a cikin acetone da a cikin ethanol (96%) | Wuce | ||
| GANO | Infrared Absorption Spectrophotometry: IR bakan yana cikin daidaituwa tare da Tranexamic acid CRS | Wuce | |
| GWADA | pH (2.2.3) | 7.0 ~ 8.0 | 7.4 |
| Abubuwa masu alaƙa (HPLC2.2.29) | Najasa A≤ 0.1 % | Ba a Gano ba | |
| Najasa B≤ 0.2% | 0.03% | ||
| NajasaC Abubuwan da ba a bayyana ba ≤ 0.10% najasa D Sauran Najasa | 0.002% 0.001% Ba a Gano ba | ||
| Jimlar ƙazantar da ba a bayyana ba ≤ 0.2% | 0.003% | ||
| Halides bayyana a matsayin Chlorides | ≤140ppm | <140pm | |
| Asara akan bushewa | ≤0.5% | 0.026% | |
| Sulfate ash | ≤0.1% | 0.027% | |
| ASSAY | Ya kamata ya kasance cikin (Bushewar tushen) 99.0% 〜101.0% | 100.1% | |
