Gliclazide (21187-98-4)
Jerin samfuran
Gliclazide magani ne na sulfonylurea na baka na maganin ciwon sukari.Farin lu'ulu'u ne ko lu'u-lu'u, mara wari da rashin ɗanɗano.
Gliclazide shine ƙarni na 2 na baka na sulfonylurea hypoglycemic wakili tare da aiki mai ƙarfi.Tsarinsa yayi kama da na toluenosulfonylurea, watau, yana aiwatar da ayyukan β-sel na pancreatic don haɓaka haɓakar insulin da haɓaka sakin insulin bayan cin glucose, wanda ba zai iya haɓaka metabolism na masu ciwon sukari kawai ba, amma kuma ingantawa ko jinkirta faruwar cutar. rikitarwa na ciwon sukari.
Ana amfani da Gliclazide musamman don nau'in ciwon sukari na II mai sauƙi da matsakaici tare da farkon farawa inda abinci da sarrafa motsa jiki kadai ba su da tasiri kuma ba tare da yanayin ketosis ba, kuma yana inganta raunin fundus da raunin metabolism da na jijiyoyin jini a cikin masu ciwon sukari.
Aikace-aikace
Ana amfani da Gliclazide don sarrafa hyperglycemia a cikin gliclazide mai amsa ciwon sukari mellitus na barga, mai laushi, mai saurin kamuwa da cuta, nau'in ciwon sukari na 2.Ana amfani da shi lokacin da ba za a iya sarrafa ciwon sukari ta hanyar sarrafa abinci mai kyau da motsa jiki ba ko kuma lokacin da maganin insulin bai dace ba.
| Gwaji | Ƙayyadaddun bayanai | Sakamakon bincike |
| Bayyanar | Fari ko kusan fari foda. | Farin foda |
| Solubility | A zahiri mara narkewa cikin ruwa;mai narkewa da yardar kaina a cikin methylene chloride;mai narkewa a cikin acetone;dan kadan mai narkewa a cikin ethanol (kashi 96). | Ya cika buƙatun |
| Ganewa | Bakan shayarwar infrared ya yi daidai da wanda aka samu tare da gliclazide CRS. | Ya cika buƙatun |
| Najasa B (Na HPLC) | ≤2pm | 0.5pm |
| Karfe masu nauyi | ≤10pm | <10ppm |
| Abubuwan da ke da alaƙa (Na HPLC) | Rashin tsabta F ≤0.1% | Ba a gano ba |
| Kowane ƙazanta da ba a bayyana ba ≤0.10% | 0.04% | |
| Jimlar ƙazanta banda F ≤0.2% | 0.11% | |
| Asarar bushewa | ≤0.25% | 0.11% |
| Sulfated ash | ≤0.1% | 0.03% |
| Ragowar kaushi (Na GC) | Ethyl acetate NMT 2500 ppm | 265pm |
| N, N-Dimethylformamide NMT 880 ppm | Ba a gano ba | |
| Assay | 99.0-101.0%, akan busassun tushe. | 100.0% |
| Kammalawa | Sakamakon gwajin ya dace da EP8. | |
